They have a point, but ultimately it’s still a biased rationalization. The idea that life is impermanent and you can’t defer doing what you care about with it is true, but it does bug me when this is posted that it’s also an imagined, hostile caricature from the perspective of a character who sees people (in particular people who have found themselves in debt slavery to his organized crime group) as just worthless losers. That’s its focus, as a putdown from that perspective; portraying a man who works a low paying job, can’t get women, commits the sins of gambling and drinking. Unstated but implied is that this is about a failure of achievement that is at its core financial, that positions himself above them both by being rich and doing fucked up things that are by his logic “meaningful”.

The OP comic is kind of an interesting contrast to that, making a similar point, but about a woman with a successful career, where that success might not hold much meaning.