The rule could be anything, as funny or as serious as you want. The universe will progress in a similar way that it has up until this point, unless your changed rule prevented it from doing so.
Some examples might be:
- The invention of currency is not allowed.
- Iron is slightly less stable.
- The Ancient Greeks are able to cultivate Silphium, which does not go extinct now.
Then all life would have likely gone extinct long before they even developed spinal columns.
Remember, pain is a fantasy your brain creates to keep you from injuring yourself.
Getting rid of that will mean zero survival instinct.