Actually curious about this myself.
Personally with ADHD and some 'tism I do have difficulty with reading / might have a bit of dyslexia but I don’t find them improving my ability to read longer texts any better as “my eyes get fatigued” (don’t know how to explain it). What does help myself is larger text, shorter paragraphs and larger line spacing.
I don’t have a lot of input on this sadly but I would believe that the audio thing you mentioned could probably easily be fixed with pipewire.
As an example you can look at qpwgraph and see that you can pipe one input into several programs at once. I’m however unsure how KVM will handle it.