90% of drug candidates fail in clinical trials

couple of reddit threads suggest that this is something you can do, but you have to be evasive around american border guard later if you go in person

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i mean i don’t think about it as a separate budget line because if you don’t have that you get police raids and investigation instead of normal business, but yea. insulin is purified using HPLC, so at all times you get some of analytical data about fractions you just made, so some of QC, not all, but already something, already happens at this point

my point is that actual manufacturing costs will be low because biotech scalability logic is that you need to make yeast or something that makes peptide you like and then all you need to do is keep bioreactor alive and happy. lots of what is left is in purification

also it’s an injectable so it’s gonna be kept to some standards that non-injected drugs aren’t. whoever comes up with insulin pill will be printing money

there are multiple short-acting and long-acting insulins because you can’t patent other people’s things, but now it’s all off-patent. just take your stainless steel bioreactor and preparative HPLC, cook up a batch, wait ten years for biosimilar approval and you’re good to go

because unlike with small molecule drugs, when cooking up generic biopharmaceutical there’s extra approval process that amounts to a tiny clinical trial https://en.wikipedia.org/wiki/Biosimilar this and type of economics of scale that there is with biologicals makes manufacture at large scale way more preferable. these requirements were loosened a bit over time

I know not every state can or are willing to do this

this kind of thing scales well, i see no reason why after california has it set up, other states couldn’t get insulin from them, or chip in

it might just be in glass vial and freezing broke it

the problem is that there is natural (as in, unmodified) cheap generic insulin available, it’s just that it sucks compared to everything else. you see, insulin is a peptide that is supposed to appear, do some signalling, then disappear and unmodified insulin copies this thing exactly. the problem is, most of the time when peptide is supposed to work as a pharmaceutical, you don’t want to do that, you’d like insulin to last longer than usual, which means changes to it that make breakdown slower, or adding something that makes it stick to albumin, which has similar effect because it hides insulin somewhere enzymes can’t reach it and also it makes it start acting slower. this means less frequent dosing and less changes in insulin activity over time. there are also other insulins that start acting faster than natural, and this is also due to a couple of modifications in its structure

for another example, ozempic was not the first drug in its class, it’s also a modified peptide, and it can be injected s.c. once a week, compared to previous iteration (liraglutide) that requires daily injections. if natural peptide is injected i.m. instead, its halflife is half an hour, and in serum it’s only two minutes (it gets released a bit slower than it is metabolized)

manufacturing costs are about the same for any variant, most of it is in purification. patents for a couple of these have expired anyway by now, but if manufacturing is limited then price can be set arbitrarily high (see daraprim)

because it’s packed with nazis and cryptobros with their spam. moderation is very limited by design

yes you can do it and it’s so easy it sometimes happens accidentally https://en.wikipedia.org/wiki/False_memory https://en.wikipedia.org/wiki/Lost_in_the_mall_technique

strictly speaking you don’t need machines for it but if there is any that would be rightwing propaganda enterprise

btw did you know that zucc studied psychology? and that research on this would be maybe not the hottest shit by the time he studied, but at least well disseminated?

this is how 238Pu ceramic pellets for space probe generators look like, no fission required just alpha decay. If it was fission, it wouldn’t need to glow like this entire time because you can just turn it off

here if you need anything over certain power (6kW; depends on country i guess) you need a three phase installation, and even if you get single phase, it’s really handled as three phase split between single phase customers (a block gets three phase supply, then splits flats in three groups, each group gets connected to one phase). this gets supplied by a distribution transformer that might serve somewhere around 200 people per (in residential areas)

i understand that sometimes americans also get distribution like this, with 208/120 three phase coming from substation, without 240v available

american version would probably only have two phases at best, and possibly just one

wait, how do you route cables in there? is there just a massive bundle right through the middle?

ye except that depending on how paranoid are you this also means that all personal/small instances will be always suspicious and most of popular instances allow lots of that by default

Absolutely none, and it’s by design. All you need to do is setup an instance and everything you might need gets right into database

if you have an antenna with impedance of, say, 200 ohms, then you need to match it to transmitter impedance of 50 ohms, or else most of power output from transmitter would be bounced back and will damage output stage of amplifier. because on receive currents are tiny, you can wing it by just using it without any match and connecting it directly

transformers are not the only way to do this, and some other circuits can be used instead. if you take a transformer with 1:2 winding ratio, then if on one side current is 1 and voltage is 1, then on the other current will be 0.5 and voltage 2, which means that impedance increases 4x. in EFHW, it’s 1:7 winding ratio and impedance ratio is 49x, which works for end-feeding a half-wave dipole, just as expected (from 50 ohm to ~2500 ohm). that transformer is a limitation on power usable in this antenna and main reason to use this type of antenna is mechanical

most importantly, transformers work nicely only if you have real impedances, so your antenna has to be resonant anyway. l- or pi-network tuner will also handle complex impedances so doublet or random wire will work nicely with it, as long as you can accept weight and losses in tuner

how compact and what do you want to do with it? if it’s for receive only, the most compact you can get is ferrite rod antenna, but it’s very different from usual wire antennas used for transmission. if using wire antennas, random wire would be fine

it depends on whether you want to transmit or not. if not, you can just use random wire antenna

random wire antenna is exactly what it says on the tin - length of random wire strung up as high as you can, as long as you can make it work. the other part is ground, where you might want to lay some lengths of wire and connect them in a single point, to act as radio ground. it won’t have right impedance (probably 50 ohm) but for receive, this is ok - it’ll be probably usable, and you can amplify signal without penalty because amplifier noise will be much smaller than atmospheric noise already present. the amount of power bouncing around is tiny and can’t damage anything

if you want to transmit, you’ll need more elaborate antenna. what you can use depends on whether do you have a tuner like neidu3 describes or not. if you do, common choice is doublet which is a specific length of wire connected to tuner with a 400-ohm parallel line. if you don’t, common choice is halfwave dipole which is halfwave long, and put as high as you can get, either vertical or horizontal, but for practical reasons mostly horizontal, or monopole, that is quarterwave long, but requires lots of wire on ground to act as radio ground. you can make them shorter using coils, but this makes bandwidth narrower. in any case, it’ll be need to be tuned to your band in question, for which you need a tool like nanoVNA. tuner also narrows your bandwidth, but you can retune it so it doesn’t matter that much. (it’c called instantaneous bandwidth)